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Constellation banks $22M for ambitious epigenetics play

Constellation Pharmaceuticals

A checklist for drug company CEO’s

1. All drugs in “the pipeline” have to have head to head clinical trials against current drugs on the market, especially generics, with a focus on patient outcomes.

Tylenol Creator Dies As J&J Scandal Intensifies

There is a sad irony here. Last Thursday, Robert McNeil, who concocted Tylenol back in 1955, passed away at age 94. After more than a half century of phenomenal success, his death occurred just as Johnson & Johnson became embroiled in a quality-control scandal over several recalls of dozens of products, most notably different forms of Tylenol (see background here and here )

NormOxys gets $17.5M to fund PoC work on new drug class

Wellesley, MA-based NormOxys has wrapped a $17.5 million Series B round , which the developer says should be enough to cover the tab for its crucial proof-of-concept work. About a year from now the company should have PoC data for both cancer as well as heart failure, CEO Martin Tolar tells FierceBiotech , offering a much clearer picture of the full potential of its development platform. NormOxys is working on a new class of therapeutics-dubbed oxyrens-which essentially restores the needed level of oxygen in diseased “hypoxic tissues.” Anyone familiar with the way heart failure destroys the body can understand the concept in play here.

Floyd Landis: The Isotopes Weren’t Lying, After All

This post from 2006 on the science behind Floyd Landis’s suspicious steroid blood tests set my blog record for comments – the debate went on and on about Landis, about the lab that reported the results, about how the samples were handled, etc. Well, Landis has now admitted using performance-enhancing drugs for most of his career.

The Forest – A Litmus Test for Every Medical Product Marketer

Of Cambridge, MA Interest Only

Every year there’s a big Cambridge Science Festival , which many companies and institutions around here get involved with.

Try It At Home

Technical book author (and occasional commenter here) Robert Bruce Thompson has a channel on YouTube called “The Home Scientist” that’s quite interesting. Many of these seem to be companion videos for his book, The Illustrated Guide to Home Chemistry Experiments . This is real, well-done chemistry with reagents that can be easily purchased and manipulated by a competent non-chemist

A balanced approach to Avandia data

-there is not enough evidence to say Actos is any safer than Avandia. – given that there are no head to head studies comparing the two, comparing separate, retrospective studies is not good practice and best avoided (this is precisely what Dr

Is the Critical Path Initiative in Critical Condition? Is the Advancing Regulatory Science Initiative Replacing the Critical Path?

Does anyone remember the FDA's Critical Path Initiative (CPI)?